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Invention disclosures received from NIH on October 9 1997 after forwarding for publication in the Federal Register

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Diagnostic Reagents And Vaccines For Multiple Genotypes Of Hepatitis C Virus

Description of Invention:
The invention describes the complete nucleotide and deduced amino
acid sequences of the envelope 1 (E1) gene of 51 hepatitis C
virus (HCV) isolates from around the world and the grouping of
these isolates into twelve distinct HCV genotypes. More
specifically, this invention relates to the oligonucleotides,
peptides and recombinant proteins derived from the envelope 1
gene sequences of these isolates and to diagnostic methods and
vaccines that employ these reagents.

Inventors:
J Bukh, RH Miller, RH Purcell (NIAID)

Patent Status:
Serial Nos. 08/466,601 and 08/468,570 filed 06 Jun 95 (DIV of
U.S. Patent 5,514,539 issued 07 May 96)

Portfolios:
Infectious Diseases - Research Materials
Infectious Diseases - Therapeutics, anti-virals


For additional information, please contact:
George Keller, Ph.D.
Office of Technology Transfer
National Institutes of Health
6011 Executive Boulevard, Suite 325
Rockville, MD 20852-3804
Phone: 301/496-7057 ext 246
Fax: 301/402-0220
E-mail: KellerG@od.nih.gov
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Antigenic Protein Of Borrelia Burgdorferi

Description of Invention:
This patent application describes a 39 kDa protein (P39) that is
species-specific and expressed by all North American and European
B. burgdorferi isolates. The discovery includes the cloning and
expression of the gene for P39 in E. coli and the use of P39 as a
diagnostic antigen for the serodiagnosis of Lyme borreliosis.
The P39 described in this invention report has been found not
only to be species-specific, but reactive only with human Lyme
borreliosis sera. This suggests that any patient's serum that is
shown to react to P39, irrespective of the patient's clinical
picture, can be diagnosed as having or having had Lyme
borreliosis.

Inventors:
WJ Simpson, TG Schwan (NIAID)

Patent Status:
Serial No. 08/396,957 filed 01 Mar 95 (DIV of U.S. Patent
5,470,712 issued 28 Nov 95)

Portfolio:
Infectious Diseases - Diagnostics, bacterial

For additional information, please contact:
George Keller, Ph.D.
Office of Technology Transfer
National Institutes of Health
6011 Executive Boulevard, Suite 325
Rockville, MD 20852-3804
Phone: 301/496-7057 ext 246
Fax: 301/402-0220
E-mail: KellerG@od.nih.gov
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Versatile Reagent For Detecting Murine Leukemia Viruses

Description of Invention:
Monoclonal antibodies directed at the proteins of murine leukemia
viruses (MuLVs) have some value as immunological reagents, but
differ greatly in their applicability. The kit described in this
invention uses a monoclonal antibody designated 83A25, which
identifies almost all ecotropic, xenotropic, polytropic, and
amphotropic MuLVs. It can be used in a wide variety of
procedures, including focal immunofluorescence assays on live or
fixed monolayers, immunoblotting, immunoprecipitation,
immunohistochemical, and flow cytometric procedures. This kit
overcomes some of the problems associated with prior methods,
which may not efficiently precipitate proteins or react in
immunoblots, are not capable of detecting MuLVs belonging to all
classes with a single reagent, and may not efficiently neutralize
all MuLVs.

Inventors:
LH Evans, WJ Britt (NIAID)

Patent Status:
Serial No. 08/046,352 filed 08 Apr 93

Portfolios:
Infectious Diseases - Diagnostics, viral, non-AIDS
Infectious Diseases - Research Materials

For additional information, please contact:
George Keller, Ph.D.
Office of Technology Transfer
National Institutes of Health
6011 Executive Boulevard, Suite 325
Rockville, MD 20852-3804
Phone: 301/496-7057 ext 246
Fax: 301/402-0220
E-mail: KellerG@od.nih.gov